3.3. Exposure Facts
Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).
Each other Body mass index and lbs was basically synchronised having BMD, and you will BMC symptoms together with most powerful Pearson’s relationship coefficients was in fact receive ranging from lbs and you may BMC overall hip and trochanter regions and you may the fresh weakest of them were ranging from Body mass index and you can femoral shoulder BMC. The brand new correlations between years and you may BMD and BMC symptoms was indeed bad (Desk cuatro).
This-adjusted ratio from BMD and you will BMC variation explained from the Body mass index and you may weight was shown in Dining table 5. Weight had a tendency to inform you deeper variations in BMD and BMC shipments anyway the brand new studied skeletal web sites as compared to Bmi. This is reflected of the steeper mountain (?) of respective linear regression outlines. The number one difference between BMD and you will BMC shipments searched within trochanter BMC accompanied by lumbar BMC to have pounds. Weight is an important predictor away from BMD and you will BMC type inside more mature Iranian guys.
cuatro. Talk
In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. nur Tattoo-Dating Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.
This new elements by which fat exerts positive effects to the BMD standing are not totally clear. Brand new putative method importance regarding fatty tissue to have skeletal ethics probably resides in the fresh part of several adipokines from inside the limbs restorations by way of impact on one another formation and you will resorption. Has just, bones could have been considered an endocrine organ impacting fat handle and sugar homoeostasis from strategies away from limbs-derived issues instance osteocalcin and you can osteopontin [23, 34–36]. The putative crosstalk ranging from body weight and the skeleton comprises a great homoeostatic opinions program where adipokines and you can particles secreted by the osteoblasts and you can osteoclasts portray the web link off an active bones-adipose axis [34–36]. Carrying excess fat is additionally from the BMD by the conversion process of androgen to help you the hormone estrogen , which improves limbs size both in folks [38, 39] and you will maintains compliment plasma levels of insulin and you can regulating facts in addition to insulin-particularly progress basis-step 1, leptin, and you may adiponectin . While doing so, carrying excess fat brings cushioning to the cool in the eventuality of a great slide . But not, the fresh new systems whereby most of these situations occur remain unclear.
